Development and validation of an innovative approach to estimating FVIII levels and designing personalised doses in the prophylactic treatment of haemophilia A: based on the principle of the two-compartment model
The proposed method for estimating FVIII PK parameters and levels demonstrates high accuracy and has the potential for precision dosing.
Authors
- Xuemei Wu (ORCID: https://orcid.org/0000-0003-1640-7385)
- Maobai Liu (ORCID: https://orcid.org/0000-0002-8382-7868)
- Qingxia Liu (ORCID: https://orcid.org/0000-0002-4100-5735)
- Zipeng Wei (ORCID: https://orcid.org/0000-0002-9847-337X)
- You Zheng (ORCID: https://orcid.org/0000-0001-8169-9412)
- Baohua Xu
- Feng'e Yang (ORCID: https://orcid.org/0000-0001-6357-750X)
- Jianxing Zhou (ORCID: https://orcid.org/0000-0003-4405-0440)
- Shuxia Zhang (ORCID: https://orcid.org/0009-0008-8347-8152)
- Meijuan Huang (ORCID: https://orcid.org/0000-0002-2536-9600)
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1136/bmjopen-2024-097053
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00