Molecular insights into the relationship between sustained CRP elevation and endothelial dysfunction in axial spondyloarthritis
Sustained CRP elevation in axSpA is strongly linked to increased CV risk, endothelial dysfunction and atherosclerosis. IL-6, CDCP-1 and PON-3 emerge as key mediators connecting inflammation to CV risk. Anti-tumour necrosis factor-α therapy improved the metabolic and inflammatory profile and modulated IL-6, CDCP-1 and PON-3 levels, supporting its role in managing CV risks in axSpA.
Authors
- E. Martin-Salazar (ORCID: https://orcid.org/0000-0001-5886-9030)
- Clementina López‐Medina (ORCID: https://orcid.org/0000-0002-2309-5837)
- Lourdes Ladehesa-Pineda (ORCID: https://orcid.org/0000-0002-3890-2224)
- M. Ruiz-Ponce (ORCID: https://orcid.org/0000-0001-8713-7760)
- Nuria Barbarroja (ORCID: https://orcid.org/0000-0002-0962-6072)
- J. Calvo-Gutiérrez (ORCID: https://orcid.org/0000-0001-6822-5589)
- E. Moreno-Caño
- D. Ruiz (ORCID: https://orcid.org/0000-0003-4197-4939)
- Eduardo Collantes‐Estévez (ORCID: https://orcid.org/0000-0002-7647-6289)
- María Ángeles Puche-Larrubia (ORCID: https://orcid.org/0000-0002-1526-0978)
- C. Pérez‐Sánchez (ORCID: https://orcid.org/0000-0002-1903-5970)
- L. Cuesta-López (ORCID: https://orcid.org/0000-0003-1450-8131)
- C. López-Pedrera (ORCID: https://orcid.org/0000-0003-2067-4603)
- I. Arias de la Rosa (ORCID: https://orcid.org/0000-0002-1145-4935)
- P. Segui
- Pedro Ortiz-Buitrago
- Rafaela Ortega
- Alejandro Escudero-Contreras
- Antonio Manuel Barranco (ORCID: https://orcid.org/0009-0008-2142-284X)
Institutions
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital General de Tomelloso (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Hospital Universitario Reina Sofía (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- University of Córdoba (ES)
Publication Details
- Journal
- RMD Open
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-005746
- Citations
- 5
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Instituto de Salud Carlos III