The Yb@g-C<sub>3</sub>N<sub>4</sub> Dual-Functional Photocatalytic Fluoroalkylation of 2-Isocyanides with R<sub>f</sub>SO<sub>2</sub>Cl as Both a Fluoroalkyl Radical Source and HAT Reagent
The first example of the dual-functional photocatalytic fluoroalkylation of 2-isocyanides with RfSO2Cl catalyzed by Yb@g-C3N4 has been accomplished by simultaneously coupling the photogenerated electron-driven reductive production of fluoroalkyl radicals with the photogenerated hole-driven oxidative production of chloride radicals. This strategy not only fully utilizes photogenerated electron–hole pairs for bond formation but also avoids the use of exogenous chloride salts, additional redox reagents, and sacrificial electron donors/acceptors. A variety of fluoroalkylated N-heteroarenes were heterogeneously synthesized in good to high yields with excellent functional-group compatibility. Furthermore, applying sono-photocatalysis not only improves the energy efficiency but also increases the reaction rate and overall efficiency.
Authors
- Wei‐Min He (ORCID: https://orcid.org/0000-0002-9481-6697)
- Qiong-Hui Peng
- Jun Rong Jiang (ORCID: https://orcid.org/0000-0002-5542-7592)
- Li‐Juan Ou
- Zhiyong Liao (ORCID: https://orcid.org/0000-0002-3133-5394)
- Zhilin Wu (ORCID: https://orcid.org/0000-0002-0362-827X)
- Jia Peng
- Hui Dai
Institutions
- Nanjing Forestry University (CN)
- University of South China (CN)
- Hunan Institute of Technology (CN)
Publication Details
- Journal
- ACS Sustainable Chemistry & Engineering
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1021/acssuschemeng.5c03350
- Citations
- 24
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 18.98
Funders
- University of South China