Role of Myeloid-Derived Suppressor Cells (MDSCs), Specifically Monocyte-Derived MDSCs, in Type 2 Diabetes-Related Diabetic Retinopathy
The percentage of M-MDSCs in peripheral blood was significantly higher in the PDR group and positively correlated with fasting blood glucose and glycosylated hemoglobin levels. Our findings suggest that M-MDSCs, particularly in the proliferative stage of DR, may serve as potential biomarkers for disease progression and offer insights into future clinical or therapeutic strategies.
Authors
- Zhengru Huang (ORCID: https://orcid.org/0000-0003-1327-7706)
- Xiaoli Xiang (ORCID: https://orcid.org/0000-0001-7020-0962)
- Ji Zhang (ORCID: https://orcid.org/0000-0002-9274-1767)
- Zhicheng Zhang (ORCID: https://orcid.org/0000-0003-1871-117X)
- Wenxuan Xu (ORCID: https://orcid.org/0009-0008-5441-925X)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Changshu No.1 People's Hospital (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/dmso.s527411
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu University
- Natural Science Foundation of Jiangsu Province
- Nantong University
- Soochow University
- Bijzonder Onderzoeksfonds UGent