Dynamic adaptation mutations and pathogenic characterization of a mouse-adapted seasonal human H3N2 influenza virus
One A(H3N2)-MA strain has been developed that can infect and kill mice. The MA strain showed stronger replication ability and pathogenicity than the A(H3N2)-WT strain. This A(H3N2)-MA model provides a valuable basis for evaluating the effects of drugs and vaccines and for studying pathogenesis.
Authors
- Ju Sun (ORCID: https://orcid.org/0000-0002-2017-5903)
- Yuhai Bi (ORCID: https://orcid.org/0000-0002-5595-363X)
- Ning Zhang (ORCID: https://orcid.org/0000-0001-6405-5295)
- Cheng Zhang (ORCID: https://orcid.org/0000-0002-4900-231X)
- Yan Li (ORCID: https://orcid.org/0000-0001-6682-0456)
- Jing Yang (ORCID: https://orcid.org/0000-0002-2457-3634)
- Deyu Tian
- Xuefeng Duan (ORCID: https://orcid.org/0000-0002-5281-1425)
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- Early Warning (United States) (US)
- University of Chinese Academy of Sciences (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s12985-025-02793-9
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China