Effectorless Fc-fusion improves FLT3L drug-like properties for cancer immunotherapy combinations
This work was performed at, and funded by Genentech Inc. South San Francisco, CA 94080, USA.
Authors
- Alan G. Gutierrez (ORCID: https://orcid.org/0000-0002-8567-9598)
- Sivan Cohen (ORCID: https://orcid.org/0000-0001-6213-6200)
- Amy M. Berkley (ORCID: https://orcid.org/0000-0001-6032-8559)
- Wendy Sandoval (ORCID: https://orcid.org/0000-0002-4672-0762)
- Geraldine Strasser (ORCID: https://orcid.org/0000-0002-8074-8128)
- Pranay Dogra (ORCID: https://orcid.org/0000-0003-2031-9855)
- Christine Moussion (ORCID: https://orcid.org/0000-0002-1641-4094)
- Ayse Meric Ovacik
- Debarko Banerji
- Xiangdan Wang
- Yee-Seir Kee
- Ahmad Ebtikar
- Elaine Mai
- Srividya Myneni
- Laëtitia Comps‐Agrar (ORCID: https://orcid.org/0000-0002-5260-6536)
- Gautham K. Rao (ORCID: https://orcid.org/0009-0004-8867-4137)
- Yichin Liu (ORCID: https://orcid.org/0000-0003-0917-1132)
- Jérémie Decalf (ORCID: https://orcid.org/0000-0002-1113-6128)
- Travis W. Bainbridge (ORCID: https://orcid.org/0000-0002-7771-7574)
- Nga Yeung Tang (ORCID: https://orcid.org/0000-0002-5658-133X)
- Hok Seon Kim (ORCID: https://orcid.org/0000-0003-2666-2291)
- Christopher C. Kemball (ORCID: https://orcid.org/0009-0003-9068-8338)
- Evangeline Toy
- Wilson Phung (ORCID: https://orcid.org/0000-0001-7793-3931)
- James A. Ernst
- Iraj Hosseini (ORCID: https://orcid.org/0000-0001-6838-773X)
- Meredith McLerie
- Dongping He
- Mandy Kwong
- David T. Wong (ORCID: https://orcid.org/0000-0002-0290-2206)
- Greg A. Lazar (ORCID: https://orcid.org/0000-0003-2169-8703)
- Radhika Kenkre
- Yue Sun (ORCID: https://orcid.org/0000-0003-4261-2382)
- Shomyseh Sanjabi
- Jill Schartner
- Peter Day
- Pamela Chan
- Yanli Yang (ORCID: https://orcid.org/0000-0002-3810-2761)
- Anthony Ancheta
- Matt Betzenhauser
Institutions
- Microsemi (Canada) (CA)
- Discovery Centre (CA)
- Gene Therapy Laboratory (FR)
- Bioanalytica (Switzerland) (CH)
- Translational Research in Oncology (FR)
- Institute for Clinical Pharmacodynamics (United States) (US)
- Applied Technologies (United States) (US)
- Quality Systems (United States) (US)
- Atotech (United States) (US)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105822
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Icahn School of Medicine at Mount Sinai
- Genentech