Stroma areactive invasion front areas (SARIFA) in 1,298 pT3/pT4 colorectal cancers: A strong prognostic parameter complementing established morphological criteria
Our study confirms the high prognostic relevance of SARIFA across key clinicopathological subgroups of CRC and highlights its value as a meaningful complement to established morphological parameters. Given its ability to provide additional prognostic insights, our findings advocate for its inclusion in pathology reports to improve risk assessment and clinical management.
Authors
- Katja Steiger (ORCID: https://orcid.org/0000-0002-7269-5433)
- Julia Teply‐Szymanski (ORCID: https://orcid.org/0000-0002-3880-1968)
- Anne‐Sophie Litmeyer (ORCID: https://orcid.org/0009-0009-4710-6746)
- Moritz Jesinghaus (ORCID: https://orcid.org/0000-0002-0018-5661)
- Wilfried Roth (ORCID: https://orcid.org/0000-0002-4847-9693)
- Carsten Denkert (ORCID: https://orcid.org/0000-0002-2249-0982)
- Sebastian Foersch (ORCID: https://orcid.org/0000-0002-4740-6900)
- Maxime Schmitt
- Nuwar Harb
- Irina Breus
- Johannes Schraml
Institutions
- Philipps University of Marburg (DE)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Histopathology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1111/his.15501
- Citations
- 4
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Deutsche Krebshilfe