Tripartite motif 47 promotes the development of thyroid carcinoma through ADAR ubiquitination
Comprehensively, glycogen synthase kinase-3β (GSK-3β)-associated ubiquitination is critical in the TRIM47-ADAR-GSK-3β axis. This study demonstrates that TRIM47 interacted with ADAR to facilitate ADAR protein degradation via ubiquitination and GSK-3β-associated phosphorylation, which serves as a novel therapeutic avenue for TC.
Authors
- Hongzhou Liu (ORCID: https://orcid.org/0000-0002-9930-4535)
- Li Tan (ORCID: https://orcid.org/0000-0002-3755-5566)
- Xiaomin Fu
- Yuhan Wang (ORCID: https://orcid.org/0000-0003-4447-5043)
- Xiaodong Hu
Institutions
- Handan College (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s10020-025-01298-z
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province