Prompt versus Delayed Triple Therapy in COPD: Solutions to Time-Related Biases in Observational Studies
Using a trial emulation approach, prompt treatment with single-inhaler triple therapy after a COPD exacerbation was not more effective than delayed treatment at reducing the incidence of subsequent exacerbations. The method used by previous studies, suggesting significant effectiveness with prompt treatment initiation, was affected by time-related biases induced by peeking into the future. A randomized controlled trial can confirm these findings.
Authors
- Pierre Ernst (ORCID: https://orcid.org/0000-0001-9983-3608)
- Samy Suissa (ORCID: https://orcid.org/0000-0002-1281-5296)
- Michael Webster‐Clark (ORCID: https://orcid.org/0000-0002-8079-8504)
- Sophie Dell’Aniello (ORCID: https://orcid.org/0000-0002-4373-7876)
Institutions
- Jewish General Hospital (CA)
- McGill University (CA)
Publication Details
- Journal
- International Journal of COPD
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/copd.s527497
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- McGill University
- Canadian Institutes of Health Research