High- and low-risk human papillomavirus prevalence in sinonasal inverted papilloma, a retrospective study
Sinonasal inverted papilloma (SnIP) is a benign but locally aggressive tumor with a high recurrence rates and potential for malignant transformation. Human papillomavirus (HPV) has been suggested as a possible factor, though detection rates vary. This study examined the prevalence of HPV genotypes in SnIP tumor tissues from patients treated at a tertiary hospital in northeastern Mexico. A retrospective analysis of 24 cases from 2014 to 2019 was conducted using formalin-fixed and paraffin-embedded (FFPE) specimens. HPV DNA was detected in 37.5 % of specimens, with HPV-18 being the most prevalent genotype (77.8 %), frequently co-occurring with HPV-11 (71.4 %). A significant association was found between high- and low-risk HPV genotypes and tumor stage based on the Krouse classification. The low detection rate suggests that HPV may not play a primary etiological role in SnIP, but further studies are needed to clarify its involvement in SnIP progression.
Authors
- Ana Ávila (ORCID: https://orcid.org/0000-0002-4251-0696)
- Lydia Guadalupe Rivera-Morales (ORCID: https://orcid.org/0000-0001-7329-0449)
- Ana Carolina Martínez‐Torres (ORCID: https://orcid.org/0000-0002-6183-0089)
- Edmundo Erbey Castelán‐Maldonado
- Silvia Judith Hernandez-Martinez
- Ángel Zavala-Pompa
- Aldo Sebastián Flores-Flores (ORCID: https://orcid.org/0000-0003-1260-6504)
- José Manuel Vázquez-Guillén (ORCID: https://orcid.org/0000-0001-8256-4253)
- Cristina Rodrı́guez-Padilla (ORCID: https://orcid.org/0000-0001-5469-8449)
- Reyes S. Taméz-Guerra (ORCID: https://orcid.org/0000-0001-5759-0863)
- Gerardo C. Palacios-Saucedo
- Julia Oliva De Leija-Portilla (ORCID: https://orcid.org/0009-0006-6743-3646)
- Roberto Lopez-Vazquez
- Leslie Vianney Alfaro-Reyes
Institutions
- Mexican Social Security Institute (MX)
- Universidad Autónoma de Nuevo León (MX)
- Fundación Universitaria San Pablo CEU (ES)
- Hospital Universitario Dr José Eleuterio Gonzalez (MX)
- Hospital de Especialidades (MX)
Publication Details
- Journal
- Journal of the Formosan Medical Association
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1016/j.jfma.2025.07.004
- Citations
- 5
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- Universidad Autónoma de Nuevo León