Silent emergence of <i>Mycoplasma pneumonia</i> from 2022 to 2024

Objectives: Community-acquired pneumonia has been associated with increased morbidity and death, and it poses a serious threat to public health worldwide. Coughing and sneezing can spread aerosols of the Mycoplasma pneumoniae bacterium; infections are normally self-limiting and mild, but they may turn into serious or even life-threatening diseases in some individuals. Increased risk of M. pneumoniae in the post-COVID-19 situation. Materials and Methods: Retrospective research on patients infected with M. pneumoniae , including polymerase chain reaction (PCR) analysis from January 2022 to December 2024 at Mani Microbiological Laboratory Pvt Ltd. A total of 19242 cases were requested for respiratory tract illness. Fast track diagnosis - respiratory pathogen identification with the TaqMan probe test. Amplification was carried out using Rotor-Gene Q 5 plex and MIC PCR. The results analyzed were documented. Results: Over 790/19242 cases tested positive for M. pneumoniae , of which 436 individuals were male, and 354 individuals were female. In December, 201 (24%) individuals were infected with M. pneumoniae; 122 individuals were infected in the notifiable age group (2–4) as reported by the Center for Disease Control and Prevention. pre-COVID-19 and during the COVID-19 pandemic situation from 2018–2021, including (62/1156) the M. pneumoniae -infected individuals. Conclusion: In this study, an elevated number of young children were infected with M. pneumonia , leading to a high risk; children between the ages of 2-4 were infected in high numbers and were considered to be a notable one. The salient emergence of M. pneumonia e in the Southern parts of India was recorded in this study.