Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance
Altered Trp-Kyn metabolism might contribute to the pathogenesis of RA. We highlighted the association of the Trp-Kyn metabolic pathway with immune imbalance in RA and its potential value in clinical practice, particularly in early diagnosis, disease activity monitoring, and personalized treatment.
Authors
- Baochen Li (ORCID: https://orcid.org/0000-0001-5593-9697)
- Ruihe Wu
- Jing Luo (ORCID: https://orcid.org/0000-0003-2702-120X)
- Chong Gao (ORCID: https://orcid.org/0000-0001-7639-0808)
- Anqi Gao (ORCID: https://orcid.org/0000-0002-0040-4289)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-3888-6359)
- Xiaoyang Liu (ORCID: https://orcid.org/0000-0002-1202-6764)
- Rui Su (ORCID: https://orcid.org/0000-0002-4807-6229)
- Caihong Wang (ORCID: https://orcid.org/0000-0003-0817-7946)
Institutions
- Brigham and Women's Hospital (US)
- Shanxi Medical University (CN)
- Shanxi University (CN)
- Precision for Medicine (United States) (US)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s13075-025-03596-7
- Citations
- 6
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.47
Funders
- National Natural Science Foundation of China