Epstein-Barr Virus-Induced Minimal Change Disease: A Cause of Nephrotic Syndrome in Infectious Mononucleosis

Infectious mononucleosis (IM), caused by the Epstein-Barr virus (EBV), typically presents as a self-limiting illness characterized by fever, pharyngitis, and lymphadenopathy. While subclinical renal involvement is not uncommon, acute kidney injury (AKI) and nephrotic syndrome due to EBV are rare. We present the case of an 18-year-old woman with EBV-induced IM complicated by minimal change disease (MCD), resulting in nephrotic syndrome. The patient responded promptly to steroid therapy, highlighting the importance of considering EBV in the differential diagnosis of minimal change nephropathy.