Dehydrocostus Lactone Inhibits Microglia‐Mediated Neuroinflammation by Targeting <scp>CYP2A6</scp> to Improve Ischemic Brain Injury
Mechanistically, DHC inhibited neuroinflammation by binding to the target CYP2A6. Our study suggests that DHC is a promising new strategy for treating ischemic stroke.
Authors
- Hui Wu (ORCID: https://orcid.org/0000-0001-5948-5987)
- Jingxuan Zhang (ORCID: https://orcid.org/0000-0002-0346-2193)
- Dujuan Sha (ORCID: https://orcid.org/0000-0002-2461-1725)
- Xinxin Zou
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-9167-2077)
- Xu Fang (ORCID: https://orcid.org/0000-0003-4507-1294)
- Xuan He (ORCID: https://orcid.org/0000-0003-1121-9449)
- Xin Shu (ORCID: https://orcid.org/0009-0009-3252-2456)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/cns.70502
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau