LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model
Our findings demonstrated that LAG3 intrinsically limits Treg cell proliferation and function in the environment with pathological α-syn and promotes the gut-to-brain transmission of α-syn.
Authors
- Fenfen Liang
- Zhiling Zhang (ORCID: https://orcid.org/0000-0001-7807-2264)
- Weizheng Kong (ORCID: https://orcid.org/0000-0001-8683-9007)
- Si Zhu
- Xiao‐Li Dong (ORCID: https://orcid.org/0000-0002-7372-0450)
- Pingyi Xu (ORCID: https://orcid.org/0000-0001-8716-5892)
- Tingting Gan (ORCID: https://orcid.org/0000-0001-7170-9680)
- Di Hu (ORCID: https://orcid.org/0000-0003-4047-7340)
- Songlin Li (ORCID: https://orcid.org/0000-0002-1073-9779)
- Chong Li (ORCID: https://orcid.org/0000-0002-3802-1507)
- Wenyuan Guo
Institutions
- Hong Kong Polytechnic University (HK)
- Xinjiang Medical University (CN)
- Shenzhen Polytechnic University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s12974-025-03502-7
- Citations
- 6
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- National Natural Science Foundation of China
- Key Technologies Research and Development Program of Guangzhou
- Basic and Applied Basic Research Foundation of Guangdong Province