Assessment of the Potential Efficacy of Herbal Formulations in Combating Carbapenem Resistance - An Emerging Environmental Menace

In recent years, carbapenem-resistant pathogens have emerged as a critical health concern worldwide. Improper antibiotic use has been a prime driver for the proliferation of multidrug-resistant bacterial strains. Medicinal plants possess bioactive compounds with antibacterial properties that could serve as novel therapeutic agents against resistant strains. The present study explores the therapeutic efficacy of four herbal formulations, Neem oil (NO), Olive oil (OO), Jatyadi oil (JO), and Rasamanikya as alternative medicine to combat carbapenem-resistant pathogens. The comparative study evaluated the herbal formulations with known antimicrobial activity, analyzing their efficacy, mechanisms of action and potential synergies when used in combination with conventional antibiotics. The environmental impact of carbapenem resistance has been highlighted, emphasizing the need for eco-friendly and biodegradable antimicrobial solutions. It is suggested that the potential of these promising herbal alternatives evaluated in the present study would contribute to the development of safer, sustainable, cost-effective antimicrobial approaches, addressing both public health and environmental concerns.