Varying Analgesic Effectiveness of Systemic and Central Intrathecal Administration of Cyclooxygenase‐2 Inhibitors in Different Phases of Osteoarthritic Pain in Rats
This study characterises the complex mechanisms underlying OA pain, involving both peripheral and central components, and highlights the stage-specific involvement of COX-2, particularly in the spinal cord. It provides experimental evidence linking central COX-2 activity and glial cell responses to OA pain, offering insights into the temporal dynamics of pain processing and guiding the development of therapeutic strategies.
Authors
- Shiying Huang (ORCID: https://orcid.org/0000-0002-0370-1553)
- Zhi‐Hong Wen (ORCID: https://orcid.org/0000-0003-4411-044X)
- Nan‐Fu Chen (ORCID: https://orcid.org/0000-0003-1293-0603)
- Zhi‐Kang Yao (ORCID: https://orcid.org/0000-0003-4791-6078)
- Yen‐Hsuan Jean (ORCID: https://orcid.org/0000-0003-4104-5603)
- Hao‐Jung Cheng (ORCID: https://orcid.org/0000-0003-2301-7086)
- Chun‐Sung Sung
- Sung‐Chun Lin
- Zongsheng Wu
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Jimei University (CN)
- Taipei Veterans General Hospital (TW)
- Kaohsiung Armed Forces General Hospital (TW)
- National Museum of Marine Biology and Aquarium (TW)
- Pingtung Christian Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/ejp.70068
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Taipei Veterans General Hospital
- National Science and Technology Council