Metabolic plasticity of the gut microbiome in response to diets differing in glycemic load in a randomized, crossover, controlled feeding study
In healthy humans, diet impacts microbial metabolism and enzymatic activity but not the overall diversity of the gut microbiome. This emphasizes the relevance of dietary components in activating expression of specific bacterial genes and their impact on host metabolism. This trial was registered at clinicaltrials.gov as NCT00622661.
Authors
- Paul D. Lampe (ORCID: https://orcid.org/0000-0002-1399-2761)
- Orsalem J. Kahsai
- Lisa Levy (ORCID: https://orcid.org/0009-0001-3367-4760)
- Johanna W. Lampe (ORCID: https://orcid.org/0000-0003-2717-3780)
- Daniel Raftery (ORCID: https://orcid.org/0000-0003-2467-8118)
- Keith R. Curtis (ORCID: https://orcid.org/0000-0002-0453-7222)
- Marian L. Neuhouser (ORCID: https://orcid.org/0000-0002-3876-0000)
- Timothy W. Randolph (ORCID: https://orcid.org/0000-0001-8465-1588)
- Ali Shojaie (ORCID: https://orcid.org/0000-0001-8846-3533)
- Meredith A.J. Hullar (ORCID: https://orcid.org/0000-0002-5322-9568)
- Mario Kratz (ORCID: https://orcid.org/0000-0003-2660-8033)
- Yuzheng Zhang (ORCID: https://orcid.org/0000-0002-4054-6740)
- Sandi L. Navarro (ORCID: https://orcid.org/0000-0002-4260-2486)
Institutions
- University of Washington (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.06.026
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health