Digoxin toxicity with therapeutic serum digoxin concentrations
This case demonstrates that digoxin toxicity can occur at serum concentrations in therapeutic range, emphasizing the importance of clinical features in diagnosing digoxin toxicity. Current guidelines vary on the role of serum digoxin concentrations in guiding the use of digoxin-specific antibody fragments, but this case underscores its efficacy in resolving symptoms related to digoxin toxicity, even at low serum concentrations.
Authors
- Marieke A. Dijkman (ORCID: https://orcid.org/0000-0001-7937-0343)
- Nedim Cimic
- Jetske Graafsma
- Femke M. J. Gresnigt (ORCID: https://orcid.org/0000-0002-6428-8600)
- Cornelis Smit (ORCID: https://orcid.org/0000-0002-1357-9248)
- Darko Mitrović (ORCID: https://orcid.org/0000-0003-1029-6725)
Institutions
- University Medical Center Groningen (NL)
- University Medical Center Utrecht (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- 's Heeren Loo (NL)
Publication Details
- Journal
- Toxicology Reports
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1016/j.toxrep.2025.102079
- Citations
- 3
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 4.16