Boosting Hydroxyl Radical Generation with Nitrogen Vacancy–Modified Carbon Nitride for Triggering Dual Damage of Cancer Nucleus DNA–Mitochondria against Hypoxic Tumors
Collectively, the high •OH-generation efficiency, strong anticancer activity, and overall safety of the O<sub>2</sub>-independent nanoparticle opens up new avenues for in-depth study on carbon nitride-based cancer PDT strategies. This work offers new hope for the effective treatment of OSCC and other challenging cancers.
Authors
- Shuyun Xue
- Tianqi Liang (ORCID: https://orcid.org/0000-0002-8129-0518)
- Huifei Li
- Jinjia Hong
- Na Li (ORCID: https://orcid.org/0000-0002-4112-0944)
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-2754-1291)
- Chengxi Zhang
- Jie Xu (ORCID: https://orcid.org/0000-0003-3848-092X)
- Bin Zhao (ORCID: https://orcid.org/0000-0003-4533-7101)
- Xiaoyan Ren (ORCID: https://orcid.org/0000-0002-0622-7412)
- Xing Wang (ORCID: https://orcid.org/0000-0002-7667-076X)
- Jiawen Gu (ORCID: https://orcid.org/0000-0002-9433-4698)
- Meixian Liu
Institutions
- Shanxi Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/ijn.s515726
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67