Prospective evaluation of plasma pTau217 stability for the detection of Alzheimer’s disease in a tertiary memory clinic
The robust stability and low lot-to-lot variability of plasma pTau<sub>217</sub> measurement in an automated platform result in high diagnostic performance of this biomarker in the prospective evaluation of patients in a memory clinic setting. These findings support its implementation into clinical routine, offering clinicians an accessible biomarker for AD diagnosis.
Authors
- Sara Rubio‐Guerra (ORCID: https://orcid.org/0000-0001-7652-8029)
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Alberto Lleó (ORCID: https://orcid.org/0000-0002-2568-5478)
- Miguel Santos‐Santos (ORCID: https://orcid.org/0000-0003-1567-617X)
- Mireia Tondo (ORCID: https://orcid.org/0000-0002-0301-9984)
- Íñigo Rodríguez‐Baz (ORCID: https://orcid.org/0000-0003-3039-9115)
- Rosa Ferrer (ORCID: https://orcid.org/0009-0004-9477-699X)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- Nuole Zhu (ORCID: https://orcid.org/0000-0002-0015-9455)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Lucía Maure-Blesa (ORCID: https://orcid.org/0000-0001-5643-7971)
- Judit Selma‐González (ORCID: https://orcid.org/0009-0006-1021-4653)
- Ignacio Illán-Gala
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Daniel Alcolea
- Jesús García-Castro
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Complejo Hospitalario Torrecárdenas (ES)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s13195-025-01779-7
- Citations
- 3
- Primary Topic
- Cognitive Functions and Memory
- Type
- article
- Field-Weighted Citation Impact
- 6.35
Funders
- Alzheimer's Association
- BrightFocus Foundation
- Fundació la Marató de TV3
- Global Brain Health Institute
- European Commission
- Fondation Jérôme Lejeune
- Generalitat de Catalunya
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España
- Fundación Tatiana Pérez de Guzmán el Bueno
- Universitat Autònoma de Barcelona
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- National Institutes of Health
- Horizon 2020 Framework Programme
- Instituto de Salud Carlos III
- European Regional Development Fund
- National Institute on Aging