Association of glutamine metabolites in synovial fluid with the severity of temporomandibular joint osteoarthritis
Our results indicate alterations in glutamine metabolism in patients with TMJ-OA. Glutamate has potential as a diagnostic marker for TMJ-OA. The concentration of glutamine was associated with the radiographic stage and MMO of TMJ-OA patients, whereas the glutamate level was correlated with VAS pain intensity. The glutamine metabolic pathway may be critical in the pathogenesis of TMJ-OA.
Authors
- Yingjie Xu (ORCID: https://orcid.org/0000-0001-6966-6247)
- Chenxi Li (ORCID: https://orcid.org/0000-0003-1443-4769)
- Zhiqiang Song (ORCID: https://orcid.org/0000-0003-0976-419X)
- Bo Shao (ORCID: https://orcid.org/0000-0003-2376-177X)
- Zhongcheng Gong
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s12891-025-08898-0
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- Natural Science Foundation of Xinjiang Province
- National Natural Science Foundation of China