Tanshinone IIA induces ferroptosis in colorectal cancer cells through the suppression of SLC7A11 expression via the PI3K/AKT/mTOR pathway
Tan IIA induces ferroptosis in CRC by suppressing SLC7A11 expression through the PI3K/AKT/mTOR pathway. Therefore, Tan IIA may be an effective therapeutic agent in the treatment of CRC.
Authors
- Tingrui Ge
- Dong Yang (ORCID: https://orcid.org/0000-0003-3402-3668)
- Jingyi Zhou (ORCID: https://orcid.org/0000-0002-6860-6469)
- Yonggang Zhang (ORCID: https://orcid.org/0000-0002-6572-8487)
- Ping Xiang (ORCID: https://orcid.org/0000-0003-1980-1513)
- Huazhuan Li
Institutions
- The First People’s Hospital of Lianyungang (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-07-05
- DOI
- https://doi.org/10.1186/s40001-025-02842-7
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11