Case Report: “DEK::AFF2 fusion associated sinonasal carcinomas: a novel oncogenic driver and emerging therapeutic strategies”
These cases highlight the aggressive nature of <i>DEK::AFF2</i> fusion-associated carcinomas and the critical role of genetic profiling in diagnosis and management. The exceptional, first ever reported response to neoadjuvant chemotherapy in one case underscores the potential for personalized treatment strategies, warranting further investigation into targeted therapies for this rare malignancy.
Authors
- Felix Braun (ORCID: https://orcid.org/0000-0002-5296-2020)
- Alessandro Bozzato (ORCID: https://orcid.org/0000-0002-9648-8834)
- Silke Wemmert
- Maximilian Linxweiler (ORCID: https://orcid.org/0000-0002-5028-9282)
- Umut Yılmaz (ORCID: https://orcid.org/0000-0003-4940-3575)
- Abbas Agaimy (ORCID: https://orcid.org/0000-0002-0445-8161)
- Bernhard Schick
- Jan Philipp Kühn (ORCID: https://orcid.org/0000-0001-5692-8543)
- Sandrina Körner (ORCID: https://orcid.org/0000-0002-6435-2940)
- Moritz Knebel
- Veronika Flockerzi
- Benedikt Balensiefer
- Lukas Brust
- Malek Zaito
Institutions
- Universitätsklinikum des Saarlandes (DE)
- Comprehensive Cancer Center Erlangen (DE)
- Saarland University (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1611790
- Citations
- 1
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Universität des Saarlandes