CYP1B1 knockout enhanced IFN-γ production is required but not sufficient for protection of cigarette smoke-exposed mice against lethal influenza virus infection
Our results demonstrate that CYP KO in mice protects against CS-enhanced susceptibility of smokers during influenza infection. IFN-γ is required but not sufficient for the protection of CS-exposed CYP KO mice against lethal IAV infection.
Authors
- Wenxin Wu (ORCID: https://orcid.org/0000-0001-6333-6773)
- Susan Kovats (ORCID: https://orcid.org/0000-0001-5479-9952)
- Craig Miller (ORCID: https://orcid.org/0000-0002-3638-5665)
- Magdalena Chlebicz (ORCID: https://orcid.org/0000-0001-7504-0929)
- Jordan P. Metcalf (ORCID: https://orcid.org/0000-0003-4359-5270)
- Chao Xu (ORCID: https://orcid.org/0000-0003-0444-7080)
- Jeremy S. Alexander
- J. Leland Booth (ORCID: https://orcid.org/0009-0006-2031-1924)
Institutions
- Oklahoma State University (US)
- Veterans Health Administration (US)
- Oklahoma Medical Research Foundation (US)
- Oklahoma City VA Medical Center (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1600025
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- University of Oklahoma Health Sciences Center
- National Institute of General Medical Sciences
- National Center for Research Resources