Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study
This study identifies clinical data and laboratory biomarkers of COVID-19 severity and mortality using machine learning models. The study identifies SpO<sub>2</sub>/FiO<sub>2</sub> ratio to be the most important predictor for both severity and mortality. Several biomarkers were identified to modestly improve the predictions. The results also provide a baseline of SARS-CoV-2 infection during the early stages of the coronavirus emergence and can serve as a baseline for future studies that inform how the genetic evolution of the coronavirus affects the host response to new variants.
Authors
- Grace A. McComsey (ORCID: https://orcid.org/0000-0003-2690-8888)
- Walter L. Eckalbar (ORCID: https://orcid.org/0000-0003-2520-7852)
- Joann Diray‐Arce (ORCID: https://orcid.org/0000-0003-2183-4269)
- Hanno Steen (ORCID: https://orcid.org/0000-0003-0179-6648)
- Charles Langelier (ORCID: https://orcid.org/0000-0002-6708-4646)
- David A. Hafler (ORCID: https://orcid.org/0000-0003-4664-535X)
- Leying Guan (ORCID: https://orcid.org/0000-0003-0609-1073)
- Lauren I. R. Ehrlich (ORCID: https://orcid.org/0000-0002-1697-1755)
- David J. Erle (ORCID: https://orcid.org/0000-0002-2171-0648)
- Chris Bime
- Ruth R. Montgomery (ORCID: https://orcid.org/0000-0002-8661-4454)
- Annmarie Hoch (ORCID: https://orcid.org/0000-0003-0836-2164)
- William B. Messer (ORCID: https://orcid.org/0000-0002-4381-6347)
- Viviana Simon
- Esther Melamed (ORCID: https://orcid.org/0000-0001-5571-3591)
- Mary Ann Comunale (ORCID: https://orcid.org/0000-0003-2056-8915)
- Albert C. Shaw (ORCID: https://orcid.org/0000-0003-4970-7640)
- Michael R. Wilson (ORCID: https://orcid.org/0000-0002-8705-5084)
- Mark M. Davis (ORCID: https://orcid.org/0000-0001-6868-657X)
- Jintong Hou (ORCID: https://orcid.org/0000-0002-4108-4277)
- Kari Christine Nadeau (ORCID: https://orcid.org/0000-0002-2146-2955)
- Jordan P. Metcalf (ORCID: https://orcid.org/0000-0003-4359-5270)
- Bali Pulendran (ORCID: https://orcid.org/0000-0001-6517-4333)
- Rafick‐Pierre Sékaly (ORCID: https://orcid.org/0000-0002-7816-4828)
- Charles B. Cairns (ORCID: https://orcid.org/0000-0003-2291-5415)
- Nadine Rouphael (ORCID: https://orcid.org/0000-0002-2512-7919)
- Bjoern Peters
- Steven E. Bosinger (ORCID: https://orcid.org/0000-0002-2116-5061)
- Farrah Kheradmand (ORCID: https://orcid.org/0000-0001-5343-103X)
- Catherine L. Hough (ORCID: https://orcid.org/0000-0001-6425-0867)
- Ana Fernandez Sesma
- Elaine F. Reed (ORCID: https://orcid.org/0000-0002-3524-545X)
- Lindsey B. Rosen (ORCID: https://orcid.org/0000-0001-5894-3878)
- Mark A. Atkinson (ORCID: https://orcid.org/0000-0001-8489-4782)
- Joanna Schaenman (ORCID: https://orcid.org/0000-0003-1174-3961)
- Carolyn S. Calfee (ORCID: https://orcid.org/0000-0001-9208-6865)
- Steven H. Kleinstein (ORCID: https://orcid.org/0000-0003-4957-1544)
- Ofer Levy (ORCID: https://orcid.org/0000-0002-5859-1945)
- Holden T. Maecker (ORCID: https://orcid.org/0000-0003-0795-9946)
- Benjamin Haslund-Gourley (ORCID: https://orcid.org/0000-0002-8488-0759)
- Patrice M. Becker (ORCID: https://orcid.org/0000-0002-1170-8587)
- David B. Corry (ORCID: https://orcid.org/0000-0001-9729-1016)
- Nelson Iván Agudelo Higuita (ORCID: https://orcid.org/0000-0002-9363-6280)
- Elias K. Haddad (ORCID: https://orcid.org/0000-0001-6924-4300)
- Al Ozonoff (ORCID: https://orcid.org/0000-0003-4233-5899)
- Scott C. Brakenridge (ORCID: https://orcid.org/0000-0002-7327-3718)
- Alison D. Augustine (ORCID: https://orcid.org/0000-0003-0064-9785)
- Lindsey Robert Baden (ORCID: https://orcid.org/0009-0004-1752-1926)
- Impacc Network
- Monica Kraft (ORCID: https://orcid.org/0000-0003-2626-2183)
- Seung Hee Kim (ORCID: https://orcid.org/0000-0002-5949-8996)
- Florian Krammer (ORCID: https://orcid.org/0000-0003-4121-776X)
- Matt Altman
- Lucy Robinson (ORCID: https://orcid.org/0009-0003-1605-9410)
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- La Jolla Institute for Immunology (US)
- Harvard University (US)
- University of Arizona (US)
- Emory University (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- Palo Alto University (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- University of Washington (US)
- University Hospitals of Cleveland (US)
- Yale University (US)
- University of Florida (US)
- Yale New Haven Health System (US)
- National Institute of Allergy and Infectious Diseases (US)
- OU Health
- University of Oklahoma Health Sciences Center (US)
- Drexel University (US)
- The University of Texas at Austin (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-07-04
- DOI
- https://doi.org/10.3389/fmed.2025.1604388
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yale University
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- David Geffen School of Medicine, University of California, Los Angeles