Vaginal microbiome dysbiosis and sexually transmitted infections correlate with concentrations of immunoglobulin isotypes in human cervicovaginal mucus: insights into HIV-1 transmission
Importantly, our study builds on previous work, providing a potential mechanism by which BV and STIs may modulate immunoglobulin isotype and subclass content in the CVM. These results highlight the need for proper treatment of BV and other STIs, as this could impact the effectiveness of HIV-1 vaccines targeted at enhancing specific immunoglobulin responses in the cervicovaginal mucosa.
Authors
- Matrona Akiso (ORCID: https://orcid.org/0000-0002-3665-9304)
- Thomas J. Hope (ORCID: https://orcid.org/0000-0001-7183-8319)
- Ann M. Carias
- Michael D. McRaven (ORCID: https://orcid.org/0000-0002-3098-1394)
- Marianne Mureithi (ORCID: https://orcid.org/0000-0001-9119-3167)
- Ruth Chirchir
- Janet Kombo
- Omu Anzala (ORCID: https://orcid.org/0000-0001-5186-1415)
- Sarah Joseph
- Joel Musando
- Israel Abook
- Print Koi
Institutions
- Northwestern University (US)
- University of Nairobi (KE)
- Imperial College London (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1627807
- Citations
- 1
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- National Institutes of Health