Dynamics of HBsAb persistence and associated BCR IgG-H CDR3 repertoire features in ultra-high versus extremely low responders to HBV vaccination
The prolonged maintenance of ultra-high antibody levels induced by recombinant HBV vaccines in individuals may be closely related to the characteristic <i>IGHV</i> usage and mutation frequency in individual responses. These findings could provide novel insights into the complex mechanisms of HBV vaccines and HBV infection.
Authors
- Y. Pan
- Xiaoyan He (ORCID: https://orcid.org/0000-0002-2086-563X)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-2274-6677)
- Ting-Wen Yang
- Zhi-Yong Han
- Jun Li (ORCID: https://orcid.org/0000-0002-7236-8088)
- Wanbang Sun
- Xinsheng Yao (ORCID: https://orcid.org/0000-0002-4733-8899)
- Lina Sun
- Yangyang Li (ORCID: https://orcid.org/0009-0006-0522-2157)
Institutions
- Zunyi Medical University (CN)
- The First People's Hospital of Guiyang (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1587553
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35