Targeting revascularization via tryptophan-indole-NETs axis: the synergistic power of acupuncture and rt-PA thrombolysis in ischemic stroke
The degradation of NETs via the tryptophan-indole pathway may facilitate the restoration of vascular structure and function following ischemic stroke. Acupuncture has the potential to modulate this pathway, thereby possibly extending the therapeutic window for rt-PA thrombolysis.
Authors
- Yi Zhao (ORCID: https://orcid.org/0000-0002-9908-0084)
- Chengfeng Li (ORCID: https://orcid.org/0000-0002-7061-2796)
- Zhiwei Fang (ORCID: https://orcid.org/0000-0002-6647-8248)
- Si-Qi Chang
- Yawen Xia (ORCID: https://orcid.org/0000-0003-0052-7497)
- Guang-Xia Ni (ORCID: https://orcid.org/0000-0002-6775-5075)
- Mingliang Gao (ORCID: https://orcid.org/0000-0002-6386-8953)
- Xinyu Liu (ORCID: https://orcid.org/0000-0003-4777-8533)
- Zihao Peng
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.3389/fneur.2025.1596158
- Citations
- 1
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province