Clinical characteristics of AATD-related COPD patients vary with age at diagnosis: data from the EARCO international registry
Patients diagnosed at an older age had lower tobacco exposure and less severe disease. This suggests that subclinical symptoms may contribute to delays in diagnosis, as COPD features can be subtle or under-recognised until later in life. Our findings highlight the importance of considering AATD in all COPD patients, regardless of age, to avoid missed or delayed diagnoses.
Authors
- Carlota Rodríguez‐García
- Kenneth B. Chapman (ORCID: https://orcid.org/0000-0002-1799-3411)
- Juan Luis Rodríguez Hermosa (ORCID: https://orcid.org/0000-0003-0552-2484)
- María Torres‐Durán (ORCID: https://orcid.org/0000-0001-6710-3766)
- Seda Tural Önür (ORCID: https://orcid.org/0000-0002-0657-0392)
- Hanan A. Tanash (ORCID: https://orcid.org/0000-0002-0913-2347)
- José Luís López-Campos (ORCID: https://orcid.org/0000-0003-1703-1367)
- Angelo Guido Corsico (ORCID: https://orcid.org/0000-0002-8716-4694)
- Jens‐Ulrik Stæhr Jensen (ORCID: https://orcid.org/0000-0003-4036-0521)
- C. Guimarães (ORCID: https://orcid.org/0000-0001-6262-3738)
- José María Hernández Pérez (ORCID: https://orcid.org/0000-0002-2920-212X)
- Tahsin Gökhan Telatar (ORCID: https://orcid.org/0000-0002-3261-3464)
- Alice Margaret Turner (ORCID: https://orcid.org/0000-0002-5947-3254)
- Yelda Varol (ORCID: https://orcid.org/0000-0003-4604-7173)
- Christian Friedrich Clarenbach (ORCID: https://orcid.org/0000-0003-2158-2321)
- İpek Özmen (ORCID: https://orcid.org/0000-0002-3448-3675)
- Dilek Karadoğan (ORCID: https://orcid.org/0000-0001-5321-3964)
- Maria Sucena (ORCID: https://orcid.org/0000-0002-0115-7080)
- Eva Bartošovská
- Paul Ellis
Institutions
- University of Copenhagen (DK)
- Izmir University (TR)
- University Health Network (CA)
- Recep Tayyip Erdoğan University (TR)
- Lund University (SE)
- Charles University (CZ)
- University of Pavia (IT)
- Toronto Western Hospital (CA)
- Instituto de Salud Carlos III (ES)
- University Hospital Complex Of Vigo (ES)
- Gentofte Hospital (DK)
- Hospital Clínico San Carlos (ES)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Chest Diseases Hospital (KW)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Hospital da Senhora da Oliveira Guimarães (PT)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- University Hospital of Zurich (CH)
- Hospital de Santo António (PT)
- Sağlık Bilimleri Üniversitesi (TR)
- Yedikule Teaching Hospital (TR)
- Instituto de Biomedicina de Sevilla (ES)
- Skåne University Hospital (SE)
- Thomayer University Hospital (CZ)
- Policlinico San Matteo Fondazione (IT)
- Hospital Universitario Virgen del Rocío (ES)
- Universidad de Sevilla (ES)
- University of Birmingham (GB)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1186/s12890-025-03782-y
- Citations
- 2
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Sanofi
- CSL Behring
- European Respiratory Society
- National Institute for Health and Care Research
- Department of Health and Social Care
- Grifols