Synthesis And Biological Activity Of Some New Stilbene Derivatives And Their Analogues

The current research was aimed at the synthesis of cis stilbene derivatives and testing their anti-cancer abilities. Various cis stilbenes substituted on the olefinic bridge were prepared and their characterizations were given using IR, NMR and MASS spectra. Sequences of the compounds that were tested regarding their cytotoxic effect on MCF-7 and HeLa cell lines. Of all the compounds, Compound 4a that was a methyl ester showed stronger activities against MCF-7 and HeLa cell lines with the IC50 value of 22.24 µm and 27.43 µm respectively