Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase
These findings strongly suggest that the human TDG is not involved in the aberrant DNA repair of AA-induced DNA damage.
Authors
- Francis Johnson (ORCID: https://orcid.org/0000-0002-7796-7653)
- Bakhyt Matkarimov (ORCID: https://orcid.org/0000-0003-0775-7324)
- Sabira Taipakova (ORCID: https://orcid.org/0000-0001-9499-1682)
- Radha Bonala
- Viktoriya S. Sidorenko (ORCID: https://orcid.org/0000-0002-3881-5702)
- Dmitry O. Zharkov (ORCID: https://orcid.org/0000-0001-5013-0194)
- Gulzhan Zhamanbayeva (ORCID: https://orcid.org/0000-0002-7450-2746)
- Murat K. Saparbaev (ORCID: https://orcid.org/0000-0002-4630-1074)
- Diana Manapkyzy (ORCID: https://orcid.org/0000-0003-3371-4459)
Institutions
- L. N. Gumilyov Eurasian National University (KZ)
- Centre National de la Recherche Scientifique (FR)
- State University of New York (US)
- Al-Farabi Kazakh National University (KZ)
- Novosibirsk State University (RU)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Institute of Chemical Biology and Fundamental Medicine (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- Stony Brook University (US)
- Nazarbayev University (KZ)
Publication Details
- Journal
- PeerJ
- Published
- 2025-07-04
- DOI
- https://doi.org/10.7717/peerj.19577
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche