Comprehensive genomic profiling and immunohistochemical analysis of prepubertal‐type testicular neuroendocrine tumours in postpubertal patients reveal a possible relationship with small intestinal neuroendocrine tumours

Immunohistochemistry revealed varying levels of positivity with intestinal markers in our cases. In two cases where CGP was performed, molecular alterations previously described as characteristic of small intestinal neuroendocrine tumours were identified. These findings suggest intestinal differentiation in these tumours and a possible relationship to small intestinal neuroendocrine tumours. This could also pose differential diagnostic challenges. Therefore, investigation of the gastrointestinal system is recommended in such cases to exclude metastatic lesions.