Bidirectional Mendelian Randomization Study: Unraveling the Link Between Idiopathic Pulmonary Fibrosis and Cardiovascular Disease
The bidirectional MR study suggests a potential negative influence of large artery atherosclerosis stroke on IPF, hinting at a protective role of IPF in stroke incidence. The absence of significant associations with other CVDs and IPF implies a more complex relationship than previously considered. Further research is needed to clarify the intricate connections between IPF and CVD.
Authors
- Liang Yang (ORCID: https://orcid.org/0000-0001-9675-5253)
- Lijuan Hu (ORCID: https://orcid.org/0000-0002-6889-1650)
- Mingyuan Xu
- Yongtong Cao (ORCID: https://orcid.org/0000-0002-8904-3060)
- Yun Zhou (ORCID: https://orcid.org/0000-0003-3230-3148)
- Ruoyu Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Annals of Human Genetics
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1111/ahg.12605
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China