Interconnections of insulin/IGF‐1 signaling and autophagy abnormalities in Alzheimer's disease
Levels of insulin/insulin-like growth factor 1 (INS/IGF-1) factors in late-onset Alzheimer's disease (LOAD) cells are higher than in healthy old controls. AKT activation by INS/IGF-1 signaling is specifically diminished in LOAD cells. INS/IGF-1/AKT/forkhead box protein O1/mechanistic target of rapamycin kinase related endocytosis/autophagy are disrupted in LOAD cells. Intracellular endocytic/autophagic structure distribution is altered in LOAD cells. INS/IGF-1 reverses endocytic/autophagic processes in LOAD versus old control cells.
Authors
- Mariana K. Bormann
- Arthur J. Siegel (ORCID: https://orcid.org/0000-0002-6795-5229)
- Elísio Alberto Evangelista (ORCID: https://orcid.org/0000-0002-8045-5237)
- Yoon Lee (ORCID: https://orcid.org/0000-0002-7851-172X)
- Jin‐feng Xuan
- Wang Liao (ORCID: https://orcid.org/0009-0006-4537-3523)
- Ruiyi Li (ORCID: https://orcid.org/0000-0002-6414-4834)
- Lucas R. Trambaiolli (ORCID: https://orcid.org/0000-0001-7824-1929)
- Kai‐Christian Sonntag (ORCID: https://orcid.org/0000-0001-7979-8171)
- Woo‐In Ryu
- Jun Liu (ORCID: https://orcid.org/0000-0001-9202-5878)
- Bruce M. Cohen (ORCID: https://orcid.org/0000-0002-8861-6285)
- Brent P. Forester
- Haley Dion
Institutions
- Tufts University (US)
- Harvard University (US)
- McLean Hospital (US)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- China Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70099
- Citations
- 6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- McLean Hospital
- National Institute on Aging