Integrative analysis of cholesterol homeostasis reveals prognostic subtypes and immune features in clear cell renal cell carcinoma
Cholesterol homeostasis signature serves as a potential biomarker for prognosis, immune microenvironment status, and clinicopathological characteristics in ccRCC. Genes related to cholesterol homeostasis, such as SREBF2, may offer new therapeutic targets for immunomodulation in ccRCC.
Authors
- Minghao Deng
- Zhenhua Jin
- Anli Zhu
- Weizhuo Wang (ORCID: https://orcid.org/0000-0002-1225-4011)
- Dong Zhang (ORCID: https://orcid.org/0000-0002-0257-4441)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-0422-8980)
- Jian Zhu (ORCID: https://orcid.org/0000-0002-3147-4319)
- Rongchao Yang
- Aijin Peng
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1007/s12672-025-03116-8
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87