Asymmetric Total Synthesis of (−)-Lemnalemnane C
The first asymmetric total synthesis of tricyclic sesquiterpenoid lemnalemnane C, which exhibits strong <i>in vivo</i> angiogenesis-promoting activity, has been accomplished. The key synthesis steps include the construction of two five-membered rings via pinacol coupling and the stereoselective introduction of an allyl group with double-bond isomerization.
Authors
- Toyoharu Kobayashi (ORCID: https://orcid.org/0000-0002-7362-1129)
- Hisanaka Ito (ORCID: https://orcid.org/0000-0002-3803-4084)
- Yuichiro Kawamoto (ORCID: https://orcid.org/0000-0003-1245-2090)
- Rina Sugitate
Institutions
- Tokyo University of Pharmacy and Life Sciences (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c00649
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00