Mepolizumab Reduces Inflammatory Eosinophils in Nasal Polyp Tissue and Restores Histological Alterations
Tissue iEos values correlate with poor sinonasal control in CRSwNP and are reduced by treatment with mepolizumab. A greater decrease in iEos is associated with a significantly greater therapeutic effect of mepolizumab.
Authors
- Alessandra Vultaggio (ORCID: https://orcid.org/0000-0002-8775-9217)
- Andrea Matucci (ORCID: https://orcid.org/0000-0001-9368-850X)
- Pietro Orlando (ORCID: https://orcid.org/0000-0002-2372-2407)
- Lorenzo Cosmi (ORCID: https://orcid.org/0000-0002-8150-8177)
- Paola Parronchi (ORCID: https://orcid.org/0000-0002-9184-5089)
- Giuseppe Licci (ORCID: https://orcid.org/0000-0002-8124-3607)
- Manlio Milanese (ORCID: https://orcid.org/0000-0001-9626-6230)
- Oreste Gallo (ORCID: https://orcid.org/0000-0003-3426-7179)
- Alberto Minzoni (ORCID: https://orcid.org/0009-0001-2398-7712)
- Margherita Perlato (ORCID: https://orcid.org/0000-0003-1877-4517)
- Annarita Palomba (ORCID: https://orcid.org/0000-0001-5082-5041)
- Matteo Accinno
- Tiziana Tatti
- Carlo Ammatuna
- Giandomenico Maggiore (ORCID: https://orcid.org/0000-0002-2741-4460)
- Emanuele Vivarelli (ORCID: https://orcid.org/0000-0001-5955-5076)
- Barbara Brugnoli
- Oliviero Rossi
Institutions
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Florence (IT)
Publication Details
- Journal
- Journal of Investigational Allergology and Clinical Immunology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.18176/jiaci.1095
- Citations
- 3
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 4.87