FCRL3 genetic variants drive autoimmune pathogenesis in multiple sclerosis and neuromyelitis optica spectrum disorders
The findings suggest that the <i>FCRL3</i> variant (rs7528684) is associated with MS rather than NMOSD. <i>FCRL3</i> might significantly contribute to OCB synthesis, while the underlying mechanisms warrant further elucidation.
Authors
- Qi-Bing Liu
- Yongfeng Xu (ORCID: https://orcid.org/0000-0002-5820-6429)
- Zhi‐Ying Wu (ORCID: https://orcid.org/0000-0003-2106-572X)
- Haipeng Liu (ORCID: https://orcid.org/0000-0002-4212-2503)
- Hao Yu (ORCID: https://orcid.org/0009-0007-0705-4756)
- Huifen Huang (ORCID: https://orcid.org/0000-0003-2132-3733)
- Gui‐Xian Zhao
Institutions
- Fujian Medical University (CN)
- Fudan University (CN)
- Lishui University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Intelligent Health (United Kingdom) (GB)
- Second Affiliated Hospital of Zhejiang University (CN)
- Huashan Hospital (CN)
- Coventry University (GB)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-07-04
- DOI
- https://doi.org/10.3389/fneur.2025.1552149
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University