Excessive Endoplasmic Reticulum Stress in B Cells Associates With the Local Immunoglobulin Production in Severe Type 2 Chronic Rhinosinusitis With Nasal Polyps
ER stress markers were significantly upregulated in CRSwNP. Specifically, ER stress levels were significantly elevated in B cells of CRSwNP compared to controls. In type 2 CRSwNP, B-cell ER stress may play a role in promoting local IgE production.
Authors
- Weiping Wen (ORCID: https://orcid.org/0000-0002-1075-7475)
- Luo Zhang (ORCID: https://orcid.org/0000-0002-0910-9884)
- Zhaofeng Xu (ORCID: https://orcid.org/0000-0002-3253-5080)
- Yanran Huang (ORCID: https://orcid.org/0000-0001-5755-7684)
- Chunbo Li (ORCID: https://orcid.org/0000-0002-3387-4439)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-6978-7695)
- Yan Yan (ORCID: https://orcid.org/0000-0002-5752-1910)
- Jian Li (ORCID: https://orcid.org/0000-0001-6124-6619)
- Yi Wei (ORCID: https://orcid.org/0000-0002-8838-252X)
- Jieying Yan
- Claus Bachert
Institutions
- Beijing Tongren Hospital (CN)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Ghent University (BE)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- University Hospital Münster (DE)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1111/cea.70107
- Citations
- 2
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- China Scholarship Council