Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition
In this study, we uncovered molecular basal-like subtype of PC and developed a prognostic signature using ridge regression. A2ML1 was identified as a crucial regulator of EMT in PC progression.
Authors
- Gaolei Zhang (ORCID: https://orcid.org/0000-0003-4451-7864)
- Jian‐Ping Cai (ORCID: https://orcid.org/0000-0003-2793-9221)
- Jiachen Ge
- Lianyuan Tao (ORCID: https://orcid.org/0000-0003-3658-5103)
- Deyu Li (ORCID: https://orcid.org/0000-0002-6615-8316)
Institutions
- University of California San Diego (US)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1186/s12967-025-06711-z
- Citations
- 6
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Henan Provincial Science and Technology Research Project