Hyperglycemia Aggravates 6‐Hydroxydopamine‐Induced Neuronal Ferroptosis via <scp>SLC7A11</scp>‐Dependent Pathway in Diabetic <scp>PD</scp> Rat Model
Chronic hyperglycemia disrupts the cystine/SLC7A11/glutathione axis, accelerating neuronal degeneration and linking DM to PD susceptibility. SLC7A11 emerges as a potential therapeutic target to mitigate neurodegeneration in diabetic individuals at risk for PD.
Authors
- Rong Li (ORCID: https://orcid.org/0000-0003-3923-9919)
- Lintao Qu (ORCID: https://orcid.org/0000-0002-6034-1777)
- Dan Wang (ORCID: https://orcid.org/0009-0000-9631-7050)
- Yanwei Wang (ORCID: https://orcid.org/0000-0002-8964-2426)
- Ya Zhao (ORCID: https://orcid.org/0009-0002-2331-9922)
- Dan Mu (ORCID: https://orcid.org/0000-0002-4860-2620)
Institutions
- North Sichuan Medical University (CN)
- Jiaxing University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/cns.70487
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Natural Science Foundation of Sichuan Province
- Health Commission of Sichuan Province
- Key Science and Technology Program of Shaanxi Province