Cardiac safety of bedaquiline, delamanid and moxifloxacin co-administered with or without varying doses of sutezolid or delpazolid for the treatment of drug-susceptible TB
The drug regimens containing standard doses of bedaquiline, delamanid and moxifloxacin, and varying doses of sutezolid or delpazolid were not found to pose a high cardiac risk in a population without further QTc-relevant risk factors. However, close monitoring of the QTc interval remains essential in patients with TB treated with combination drug therapy with known QTc-prolonging drugs.
Authors
- Modulakgotla Sebe (ORCID: https://orcid.org/0000-0003-4330-5499)
- Rodney Dawson (ORCID: https://orcid.org/0000-0001-9804-1588)
- Bayodé Roméo Adégbitè (ORCID: https://orcid.org/0000-0003-4208-6212)
- Timothy D. McHugh (ORCID: https://orcid.org/0000-0003-4658-8594)
- Anna Jarchow-MacDonald
- Stephen H. Gillespie (ORCID: https://orcid.org/0000-0001-6537-7712)
- Alexa Dierig (ORCID: https://orcid.org/0000-0001-6505-8797)
- Kim Narunsky
- Chacha Mangu (ORCID: https://orcid.org/0009-0006-7631-6812)
- Francis Mhimbira (ORCID: https://orcid.org/0000-0001-8989-6832)
- Gibson Kibiki (ORCID: https://orcid.org/0000-0002-2826-8709)
- John Mdluli
- Angela M. Crook (ORCID: https://orcid.org/0000-0002-6174-8747)
- Daud D Peter
- Iván Noreña (ORCID: https://orcid.org/0000-0001-5092-2589)
- Hadija Semvua (ORCID: https://orcid.org/0000-0002-1352-5899)
- Robert S. Wallis (ORCID: https://orcid.org/0000-0001-6152-5183)
- Trevor Beattie
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- Patrick P. J. Phillips (ORCID: https://orcid.org/0000-0002-6336-7024)
- Laura Páramo (ORCID: https://orcid.org/0000-0003-4992-5330)
- Julia Dreisbach (ORCID: https://orcid.org/0000-0001-6625-9857)
- Gavin Churchyard (ORCID: https://orcid.org/0000-0002-4269-3699)
- Tresphory Zumba
- Andreas H. Diacon (ORCID: https://orcid.org/0000-0001-8641-6792)
- Simon E. Koele (ORCID: https://orcid.org/0000-0002-7011-667X)
- Wilber Sabiiti (ORCID: https://orcid.org/0000-0002-4742-2791)
- Ralf Stemkens (ORCID: https://orcid.org/0009-0008-6912-4163)
- Mohammed Rassool (ORCID: https://orcid.org/0000-0003-0792-9050)
- Joseph Sithole
- Michael Höelscher (ORCID: https://orcid.org/0000-0002-7642-1835)
- Letícia Muraro Wildner (ORCID: https://orcid.org/0000-0003-2553-3244)
- Christina Manyama
- Priya Solanki
- Madalo Mukoka (ORCID: https://orcid.org/0000-0001-9656-8255)
- Ian Sanne (ORCID: https://orcid.org/0000-0003-4921-5611)
- Heeran Makkan (ORCID: https://orcid.org/0000-0002-4737-7804)
- Derek J. Sloan (ORCID: https://orcid.org/0000-0002-7888-5449)
- Lindsey te Brake
- Matthew Bates (ORCID: https://orcid.org/0000-0003-0464-1529)
- Veronique de Jager (ORCID: https://orcid.org/0000-0001-6389-5575)
- Celso Khosa (ORCID: https://orcid.org/0000-0001-6701-4202)
- Marriott Nliwasa (ORCID: https://orcid.org/0000-0002-3100-5512)
- Levan Jugheli
- Bariki Mtafya (ORCID: https://orcid.org/0000-0003-3772-8671)
- Mohamed Sasamalo (ORCID: https://orcid.org/0000-0003-0732-1993)
- Issa Sabi (ORCID: https://orcid.org/0000-0002-1777-6572)
- Bruce Kirenga (ORCID: https://orcid.org/0000-0002-2023-2840)
- Larissa Hoffmann
- Stellah Mpagama (ORCID: https://orcid.org/0000-0002-0660-6930)
- Isabel Timana
- Rob E. Aarnoutse (ORCID: https://orcid.org/0000-0001-8925-969X)
- Martin J. Boeree (ORCID: https://orcid.org/0000-0002-7444-921X)
- Norbert Heinrich
- Gabriel Rojas-Ponce
- Jodie A. Schildkraut (ORCID: https://orcid.org/0000-0002-7236-8934)
- Klaus Reither (ORCID: https://orcid.org/0000-0001-6195-8237)
- Martin P. Grobusch (ORCID: https://orcid.org/0000-0002-0046-1099)
- Lilian Tina Minja (ORCID: https://orcid.org/0000-0002-9597-0207)
- Benno Mbeya
- Chaima Mouhdad
- Petra Gross-Demel
- Alia Razid
- Wandini Lutchmun
- Krista Stoycheva
- Xue Gong (ORCID: https://orcid.org/0000-0001-8121-3566)
- Robert Hunt (ORCID: https://orcid.org/0000-0001-8312-7776)
- Sven Friedrich
- Martin Peter Grobusch
- Brian H Aldana
- Ayôla Akim Adégnika (ORCID: https://orcid.org/0000-0003-3197-5946)
- Alphonce Liyoyo
- Noel Sam
- Nyanda Elias Ntinginya
- Larissa Wagnerberger
- Lucia Mokaba
- Namhla Madikizela
- Cyprian Mtweve
- Beno Huglin
Institutions
- Ifakara Health Institute (TZ)
- Uppsala University (SE)
- Radboud University Nijmegen (NL)
- University of St Andrews (GB)
- University of California, San Francisco (US)
- Utrecht University (NL)
- Center for Environmental Health (US)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Helmholtz Zentrum München (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- German Center for Infection Research (DE)
- Aurum Institute (ZA)
- Jinan Infectious Disease Hospital (CN)
- National Institute for Medical Research (TZ)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1093/jac/dkaf210
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Deutsches Zentrum für Infektionsforschung
- Bundesministerium für Bildung und Forschung
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- European and Developing Countries Clinical Trials Partnership