Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis
Plasma pTau217 showed high diagnostic accuracy for AD, DLB, and FTD. CXCL1, SNAP25, TREM1, β-synuclein, and TEK are novel markers distinguishing other dementias from AD. Noninvasive plasma biomarkers enable diagnosis and differentiation of dementias.
Authors
- Gamze Güven (ORCID: https://orcid.org/0000-0001-8576-5843)
- Erdi Şahin (ORCID: https://orcid.org/0000-0002-5792-2888)
- Hakan Gürvıt (ORCID: https://orcid.org/0000-0003-2908-8475)
- John Hardy (ORCID: https://orcid.org/0000-0002-3122-0423)
- Murat Emre
- Haşim Gezegen (ORCID: https://orcid.org/0000-0002-8954-7437)
- Merve Alaylıoğlu (ORCID: https://orcid.org/0000-0002-3396-5437)
- Elena Veleva (ORCID: https://orcid.org/0009-0004-2440-8163)
- Bedia Samancı (ORCID: https://orcid.org/0000-0003-0667-2329)
- Başar Bılgıç (ORCID: https://orcid.org/0000-0001-6032-0856)
- Owen Swann (ORCID: https://orcid.org/0000-0002-1464-0274)
- Erdinç Dursun (ORCID: https://orcid.org/0000-0003-3701-6674)
- Dervis A. M. Salih (ORCID: https://orcid.org/0000-0001-7651-8998)
- Ümran Yaman (ORCID: https://orcid.org/0000-0003-4469-8407)
- Maryam Shoai (ORCID: https://orcid.org/0000-0003-2499-8533)
- Amanda Heslegrave (ORCID: https://orcid.org/0000-0002-7290-6405)
- Duygu Gezen‐Ak (ORCID: https://orcid.org/0000-0001-7611-2111)
- Haşmet Hanağası (ORCID: https://orcid.org/0000-0001-9645-7707)
- Henrik Zetterberg
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Istanbul University-Cerrahpaşa (TR)
- UK Dementia Research Institute (GB)
- University College London (GB)
- Istanbul University (TR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70162
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Alzheimer's Drug Discovery Foundation
- European Commission
- Vetenskapsrådet
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- HORIZON EUROPE Framework Programme