Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis

Plasma pTau217 showed high diagnostic accuracy for AD, DLB, and FTD. CXCL1, SNAP25, TREM1, β-synuclein, and TEK are novel markers distinguishing other dementias from AD. Noninvasive plasma biomarkers enable diagnosis and differentiation of dementias.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-07-01
DOI
https://doi.org/10.1002/alz.70162
Citations
4
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
4.66

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article

Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis

Gamze Güven, Erdi Şahin, Hakan Gürvıt, John Hardy et al.
4 citations
Alzheimer s & Dementia
Alzheimer's disease research and treatments
4.66
article

Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis

Gamze Güven, Erdi Şahin, Hakan Gürvıt, John Hardy, Murat Emre, Haşim Gezegen, Merve Alaylıoğlu, Elena Veleva, Bedia Samancı, Başar Bılgıç, Owen Swann, Erdinç Dursun, Dervis A. M. Salih, Ümran Yaman, Maryam Shoai, Amanda Heslegrave, Duygu Gezen‐Ak, Haşmet Hanağası, Henrik Zetterberg
article en
4 citations

Abstract

Plasma pTau217 showed high diagnostic accuracy for AD, DLB, and FTD. CXCL1, SNAP25, TREM1, β-synuclein, and TEK are novel markers distinguishing other dementias from AD. Noninvasive plasma biomarkers enable diagnosis and differentiation of dementias.

Alzheimer s & DementiaVol. 21(7)
University of Wisconsin–Madison (US), Sahlgrenska University Hospital (SE), Istanbul University-Cerrahpaşa (TR), UK Dementia Research Institute (GB), University College London (GB), Istanbul University (TR), University of Gothenburg (SE)
Alzheimer's Drug Discovery Foundation, European Commission, Vetenskapsrådet, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, HORIZON EUROPE Framework Programme
Good health and well-being
Openalex Percentile: Top 5%
Alzheimer's disease research and treatments
4.66
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