Exploring the Causal Link Between Autoimmune Diseases and Pulmonary Arterial Hypertension: A Bidirectional Mendelian Randomization Study
The findings suggest a possible genetic causative link between RA and IBD and the risk of developing PAH. Conversely, genetic predisposition to MS, SLE, and T1D does not appear to influence PAH risk. Understanding these relationships may offer insights into the pathophysiology of PAH and inform screening strategies within at-risk populations.
Authors
- Dongmei Di (ORCID: https://orcid.org/0000-0002-4974-7274)
- Xiaoying Zhang (ORCID: https://orcid.org/0000-0002-8197-6798)
- Chao Ma (ORCID: https://orcid.org/0009-0009-9882-1918)
- Bin Wang (ORCID: https://orcid.org/0000-0002-7166-0482)
- Min Wang (ORCID: https://orcid.org/0000-0002-5624-6363)
- Yongxiang Qian
- Cheng Gong (ORCID: https://orcid.org/0009-0004-3641-9484)
- Yangmeina Li
Institutions
- Soochow University (CN)
- Changzhou Third People's Hospital (CN)
Publication Details
- Journal
- Global Heart
- Published
- 2025-07-04
- DOI
- https://doi.org/10.5334/gh.1445
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52