A novel approach to resilience and its links with education and Alzheimer's disease genetics
·We define a novel approach to resilience using canonical correlation analysis (CCA). ·Apolipoprotein E ε4 is linked to lower resilience, suggesting increased vulnerability. ·Genetic loci around COX7C and MINDY2 are potentially involved in higher resilience. ·This novel approach may be used for multi-cohort studies such as genome-wide association studies in the future.
Authors
- Paul J. Lucassen (ORCID: https://orcid.org/0000-0001-9708-9133)
- Diana I. Bocancea (ORCID: https://orcid.org/0000-0001-8303-8933)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Anna C. van Loenhoud
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Sven J Van Der Lee
- Jacob W. Vogel (ORCID: https://orcid.org/0000-0001-6394-9940)
- Harm J. Krugers (ORCID: https://orcid.org/0000-0002-7926-7001)
- Niccoló Tesi (ORCID: https://orcid.org/0000-0002-1413-5091)
- Maria Carrigan
Institutions
- Queen Mary University of London (GB)
- Lund University (SE)
- Amsterdam Neuroscience (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Amsterdam University of Applied Sciences (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70379
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Alzheimer Nederland
- European Research Council