Evaluation of plasma p‐tau217 for detecting amyloid pathology in a heterogeneous community‐based cohort
The Wake Forest Alzheimer's Disease Research Center (WFADRC) is a heterogeneous cohort. p-tau217 levels were lower, on average, in cognitively unimpaired participants, females, and Black participants. Plasma p-tau217 classified amyloid positron emission tomography (PET)-positive individuals with high precision and performed better than p-tau181. Cutpoints and reference ranges of plasma p-tau217 were lower compared to recently published thresholds. Combining cutpoint approaches, a four-tier system captured cohort heterogeneity.
Authors
- Christopher T. Whitlow (ORCID: https://orcid.org/0000-0003-2392-8293)
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Courtney L. Sutphen (ORCID: https://orcid.org/0000-0001-5005-2018)
- Kiran Kumar Solingapuram Sai (ORCID: https://orcid.org/0000-0002-6442-5169)
- James R. Bateman
- Marc D. Rudolph (ORCID: https://orcid.org/0000-0001-7046-1169)
- Timothy M. Hughes (ORCID: https://orcid.org/0000-0002-2919-7199)
- Samuel N. Lockhart (ORCID: https://orcid.org/0000-0002-0893-5420)
- Thomas C. Register (ORCID: https://orcid.org/0000-0002-4078-0166)
- Melissa M. Rundle (ORCID: https://orcid.org/0000-0003-4360-216X)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
Institutions
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70426
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- Wake Forest University
- Wake Forest School of Medicine
- National Institute on Aging