Long-term efficacy and safety of pexidartinib in patients with tenosynovial giant cell tumor: final results of the ENLIVEN study
Final long-term ENLIVEN results demonstrated that pexidartinib sustained clinical benefit, with increased ORR by RECIST and TVS compared to the end of the blinded phase at week 25. No new safety signals were reported.
Authors
- Andrew J. Wagner (ORCID: https://orcid.org/0000-0002-4384-9448)
- Xin Ye (ORCID: https://orcid.org/0000-0002-5929-3798)
- John H. Healey (ORCID: https://orcid.org/0000-0002-0802-1186)
- Charles Peterfy (ORCID: https://orcid.org/0000-0001-8277-6328)
- Kristen M. Tecson (ORCID: https://orcid.org/0000-0002-6732-8698)
- Hans A. J. Gelderblom (ORCID: https://orcid.org/0000-0001-9270-8636)
- Michiel A. J. van de Sande (ORCID: https://orcid.org/0000-0002-9156-7656)
- Dale E. Shuster (ORCID: https://orcid.org/0000-0003-0260-509X)
- William D. Tap (ORCID: https://orcid.org/0000-0001-7779-2796)
- Sebastian Bauer (ORCID: https://orcid.org/0000-0001-5949-8120)
- Jean‐Yves Blay (ORCID: https://orcid.org/0000-0001-7190-120X)
- Christopher W. Ryan (ORCID: https://orcid.org/0000-0002-4259-1123)
- Silvia Stacchiotti (ORCID: https://orcid.org/0000-0002-1742-8666)
- Jayesh Desai (ORCID: https://orcid.org/0000-0003-4246-9344)
- Emanuela Palmerini (ORCID: https://orcid.org/0000-0003-3406-6705)
- Margaret Wooddell (ORCID: https://orcid.org/0009-0008-3657-6614)
- Meng Qian (ORCID: https://orcid.org/0000-0002-5659-1159)
- Abdul Waheed Rajper (ORCID: https://orcid.org/0009-0000-6468-7380)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- Cornell University (US)
- Leiden University Medical Center (NL)
- Peter MacCallum Cancer Centre (AU)
- Boca Raton Regional Hospital (US)
- Centre Léon Bérard (FR)
- Dana-Farber Cancer Institute (US)
- Essen University Hospital (DE)
- Istituto Ortopedico Rizzoli (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- West German Heart and Vascular Center Essen (DE)
- Daiichi Sankyo (United States) (US)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1093/oncolo/oyae345
- Citations
- 6
- Primary Topic
- Musculoskeletal synovial abnormalities and treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.01