Chemical and Physical Stability Assessment of Devised Tacrolimus Gel for Treatment of Vitiligo

In order to retain quality and effectiveness over time, this study attempts to create and assess tacrolimus gel formulations with improved long-term chemical and physical stability. Differential Scanning Calorimetry (DSC) and DSC-photovisual approaches were among the analytical techniques used to thoroughly evaluate these gels' stability characteristics. In order to replicate actual storage circumstances, Accelerated Stability Testing (ASLT) was also carried out at various temperatures and intervals of time. The study investigates cutting-edge nano-based delivery technologies such liposomes, nanoparticles, and nanotransfersomes in order to overcome the difficulties caused by tacrolimus's poor water solubility and possible cytotoxicity. In order to improve therapeutic results, these nano-carriers seek to maximise regulated medication release and penetration into deeper layers of vitiligo-affected skin. All things considered, the results enhance tacrolimus's formulation stability and targeted distribution, providing a viable strategy for improved vitiligo therapy.