Biological Mechanisms for Allen's Rule: <scp>DNA</scp> Methylation as Mediator of the Association Between In Utero Exposure to Environmental Heat and Tibial Growth in Childhood
To our knowledge, these are the first results to identify biological mediators linking environmental heat to lower limb growth in children. The findings contribute evidence of epigenetic mechanisms relevant to Allen's rule and of the tibia as a key biomarker of early life conditions.
Authors
- Claudia Lalancette (ORCID: https://orcid.org/0000-0002-6854-4034)
- Charles E. Hilton (ORCID: https://orcid.org/0000-0003-4316-7591)
- Charles Owuor Olungah (ORCID: https://orcid.org/0000-0002-2708-609X)
- Belinda L. Needham (ORCID: https://orcid.org/0000-0001-5939-2027)
- Bilinda Straight (ORCID: https://orcid.org/0000-0002-1387-5514)
- Amy E. Naugle
- Xi Qiao (ORCID: https://orcid.org/0000-0002-3017-3549)
- Duy Ngo (ORCID: https://orcid.org/0000-0003-1033-1914)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Nairobi (KE)
- Western Michigan University (US)
- University of Michigan (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- American Journal of Human Biology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/ajhb.70086
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Science Foundation